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FGF2
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, RAS pathway related proteins, Transporters
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Astrocytes, Fibroblasts, Oligodendrocyte precursor cells, Endometrial stromal cells, Adipocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, hTERT-HME1)
Interaction
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (PubMed:28302677). Interacts with SNORC (via the extracellular domain) (By similarity). Interacts with glypican GPC3 (By similarity).
Molecular function
Developmental protein, Growth factor, Heparin-binding, Mitogen
More Types Infomation
- Recombinant Human Anti-human FGF2 Antibody Fab Fragment (MHH-357-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: IP, IF, Biosensors, FuncS
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, IP, WB
- Mouse Anti-FGF2 Recombinant Antibody (clone 0.T.50) (NEUT-800CQ)
-
- Species Reactivity: Mouse, Rat, Bovine, Human
- Type: Mouse IgG1, κ
- Application: Neut
-
- Species Reactivity: Human
- Application: ELISA
- Mouse Anti-FGF2 Recombinant Antibody (clone CBL979) (NEUT-801CQ)
-
- Species Reactivity: Human, Bovine
- Type: Mouse IgG1, κ
- Application: Neut
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: RIA, IF, FuncS
- Recombinant Anti-human FGF2 Antibody scFv Fragment (MOB-357-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FC, FuncS
- Recombinant Anti-human FGF2 Antibody Fab Fragment (MOB-357-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IF, FC, FuncS
- Recombinant Human Anti-human FGF2 Antibody scFv Fragment (MHH-357-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IP, FuncS
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FuncS, WB
- Rabbit Anti-FGF2 Recombinant Antibody (clone JM28-10) (MRO-0576-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP, FC
- Recombinant Mouse Anti-FGF2 Antibody (FB-8) (NEUT-802CQ)
-
- Species Reactivity: Cow, Human
- Type: IgG1
- Application: RIA, ELISA, Dot, Neut, WB, IHC-FoFr
- Anti-Human FGF2 Recombinant Antibody Fab Fragment (3F12E7) (TAB-048WM-F(E))
-
- Species Reactivity: Human, Mouse
- Application: ELISA, FuncS
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
- Mouse Anti-FGF2 Recombinant Antibody (clone YC058); Fab Fragment (NS-026CN-F(E))
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Human Anti-FGF2 Recombinant Antibody (clone YC056); Fab Fragment (NS-009CN-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
- Anti-Human FGF2 Recombinant Antibody (6) (TAB-049WM)
-
- Derivation: Phage display
- Species Reactivity: Human
- Type: Human Antibody
- Application: ELISA, WB
- Anti-Human FGF2 Recombinant Antibody (3F12E7) (TAB-048WM)
-
- Species Reactivity: Human, Mouse
- Application: ELISA, WB, IHC, FuncS
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