Feline infectious peritonitis (FIP) is a fatal, incurable disease that affects cats. It is caused by Feline Infectious Peritonitis Virus (FIPV), which is a mutation of Feline Enteric Coronavirus (FECV) - (Feline Coronavirus FCoV). Experts do not agree on the specifics of genetic changes that produce the FIPV. The mutated virus has the ability to invade and grow in certain white blood cells, namely macrophages. The immune system's response causes an intense inflammatory reaction in the containing tissues. This disease is generally fatal. However, its incidence rate is roughly 1 in 5000 for households with one or two cats. A nasally administered vaccine for FIP is available but controversial, and it isn't proven to be highly effective. An experimental polyprenyl immunostimulant is being manufactured by Sass and Sass and tested by Dr. Al Legendre who described survival over 1 year in three cats diagnosed with FIP and treated with the medicine. In one case study, a female cat diagnosed with dry FIP has survived 26 months from the date of definitive diagnosis.