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FLT3
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Protein class
Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, RAS pathway related proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Inhibitory neurons, monocytes, Kupffer cells, dendritic cells, Langerhans cells, Macrophages)
Immune cell specificity
Group enriched (myeloid DC, plasmacytoid DC)
Cell line specificity
Group enriched (REH, THP-1)
Interaction
Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. Interacts with FIZ1 following ligand activation (By similarity). Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2. Interacts with PTPRJ/DEP-1 and PTPN11/SHP2. Interacts with RNF115 and RNF126 (By similarity). (Microbial infection) Interacts with human cytomegalovirus protein UL7.
Molecular function
Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
- A*01:01/Human FLT3 ITD (YVDFREYEYY) MHC Pentamer (MHC-YF438)
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- Class: Class I
- Antigen: FLT3 ITD
- Antigen Species: Human
- Peptide: YVDFREYEYY
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- Species Reactivity: Human
- Application: FC, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IHC
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB
- Human Anti-FLT3 Recombinant Antibody (clone D4-3); scFv Fragment (HPAB-0182CQ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Neut
- Human Anti-FLT3 Recombinant Antibody (HPAB-0103-YC) (HPAB-0103-YC)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1, κ
- Application: ELISA, Block, FC
- Mouse Anti-FLT3 Recombinant Antibody (TAB-014CQ) (TAB-014CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC
- Human Anti-FLT3 Recombinant Antibody (TAB-013CQ) (TAB-013CQ)
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) IgG1, κ
- Application: ELISA, FC
- Human Anti-FLT3 Recombinant Antibody (clone D4-3) (HPAB-0182CQ)
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA, Neut
- Human Anti-FLT3 Recombinant Antibody; scFv Fragment (HPAB-0103-YC-S(P)) (HPAB-0103-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Block, FC
- Mouse Anti-FLT3 Recombinant Antibody; scFv Fragment (TAB-014CQ-S(P)) (TAB-014CQ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Human Anti-FLT3 Recombinant Antibody; scFv Fragment (TAB-013CQ-S(P)) (TAB-013CQ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
- Human Anti-FLT3 Recombinant Antibody; scFv Fragment (TAB-012CQ-S(P)) (TAB-012CQ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
- Mouse Anti-FLT3 Recombinant Antibody; scFv Fragment (TAB-011CQ-S(P)) (TAB-011CQ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Anti-Human FLT3 Recombinant Antibody scFv Fragment (BV10A4H2) (TAB-010CQ-S(P))
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- Species Reactivity: Human
- Application: ELISA, FC
- Human Anti-FLT3 Recombinant Antibody; Fab Fragment (TAB-012CQ-F(E)) (TAB-012CQ-F(E))
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) Fab
- Application: ELISA, FC
- Mouse Anti-FLT3 Recombinant Antibody; Fab Fragment (TAB-011CQ-F(E)) (TAB-011CQ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Anti-Human FLT3 Recombinant Antibody Fab Fragment (BV10A4H2) (TAB-010CQ-F(E))
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- Species Reactivity: Human
- Application: ELISA, FC
- Anti-Human FLT3 Recombinant Antibody (IMC-EB10) (TAB-291CL)
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- Derivation: Human
- Species Reactivity: Human
- Type: Antibody
- Application: WB, IHC, FC, Cyt, ELISA
- Human Anti-FLT3 Recombinant Antibody (TAB-012CQ) (TAB-012CQ)
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) IgG1, κ
- Application: ELISA, FC
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