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FUT3

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
Protein class

Blood group antigen proteins, Enzymes, Metabolic proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Distal enterocytes, Paneth cells, Proximal enterocytes, Intestinal goblet cells, Undifferentiated cells, Pancreatic endocrine cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A-431, hTCEpi, OE19, RH-30, SK-BR-3)

Molecular function

Blood group antigen, Glycosyltransferase, Transferase

More Types Infomation
    • Target: Lewis Y (LeY)
    • Linker: VC (valine-citrulline)
    • Drug: MMAE (Monomethyl auristatin E)

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