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FXYD5

FXYD5 (also termed dysadherin or RIC) is a structurally and functionally unique member of the FXYD family. As other FXYD proteins, FXYD5 specifically interacts with the Na,K-ATPase and alters its kinetics by increasing Vmax However, unlike other family members FXYD5 appears to have additional functions, which cannot be readily explained by modulation of transport kinetics. Knockdown of FXYD5 in MDA-MB-231 breast cancer cells largely decreases expression and secretion of the chemokine CCL2 (MCP-1). A related effect has also been observed in renal cell carcinoma cells.
Protein class

Plasma proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Pancreatic endocrine cells, Langerhans cells, Extravillous trophoblasts, T-cells, Hofbauer cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Molecular function

Ion channel

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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