Loading...
Custom Services order now ship next day

FCER1G

The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors.
Protein class

FDA approved drug targets

Predicted location

Membrane

Single cell type specificity

Group enriched (Hofbauer cells, Macrophages, Kupffer cells, Langerhans cells, NK-cells, monocytes, dendritic cells, granulocytes)

Immune cell specificity

Group enriched (non-classical monocyte, intermediate monocyte, plasmacytoid DC, classical monocyte, myeloid DC, basophil, neutrophil, NK-cell)

Cell line specificity

Group enriched (HEL, HMC-1, THP-1, U-266/84, U-937)

Interaction

IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide-linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (PubMed:8611682). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer of CD247 and FCER1G, associates with the ligand binding subunit FCGR3A to form a functional receptor complex (PubMed:28652325) (By similarity). Associated with CLEC6A (By similarity). Interacts with CLEC4E (PubMed:18776906). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with TARM1 (PubMed:26311901).

Molecular function

IgE-binding protein, Receptor

More Types Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

For Research Use Only. Not For Clinical Use.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare