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FOLR2

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.
Protein class

Metabolic proteins

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Hofbauer cells)

Immune cell specificity

Immune cell enhanced (classical monocyte, intermediate monocyte)

Cell line specificity

Cell line enriched (U-698)

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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