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GLI3
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Astrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, WM-115)
Interaction
The full-length GLI3 form (GLI3FL) interacts with SUFU and this interaction regulates the formation of either repressor or activator forms of GLI3. Its association with SUFU is regulated by Hh signaling and dissociation of the SUFU-GLI3 interaction requires the presence of the ciliary motor KIF3A (By similarity). Interacts with KIF7. The activator form of GLI3 (GLI3A) but not the repressor form (GLI3R) can interact with TRPS1. The phosphorylated form interacts with BTRC. Interacts with ZIC1. Interacts with ZIC3 (via C2H2-type domains 3, 4 and 5); the interaction enhances its transcriptional activity. Interacts with WRD11; the interaction associates EMX1 with GLI3 (PubMed:29263200). Interacts with DZIP1; retains GLI3 within the cytoplasm (PubMed:23955340).
Molecular function
Activator, DNA-binding, Repressor
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
- Recombinant Anti-human GLI3 Antibody (MOB-396)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FuncS
- Recombinant Human Anti-human GLI3 Antibody scFv Fragment (MHH-396-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: FC, RIA, Biosensors, FuncS
- Recombinant Anti-human GLI3 Antibody scFv Fragment (MOB-396-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
- Recombinant Anti-human GLI3 Antibody Fab Fragment (MOB-396-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: FC, IP, FuncS
-
- Derivation: Phage display library
- Species Reactivity: Human, Predicted to work with: Chimpanzee
- Type: Rabbit IgG
- Application: ICC, IF, WB
- Rabbit Anti-GLI3 Recombinant Antibody (clone JG83-39) (MRO-0659-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF
- Recombinant Human Anti-human GLI3 Antibody Fab Fragment (MHH-396-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: IF, Neut, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, Neut, FuncS
-
- Species Reactivity: Human
- Application: WB
- Recombinant Anti-human GLI3 Intrabody [Tat] (IAB-B069(T))
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- Species Reactivity: human
- Type: vhh-Tat
- Application: ELISA, WB, ICC, FuncS
- Recombinant Anti-human GLI3 Intrabody [+36 GFP] (IAB-B069(G))
-
- Species Reactivity: human
- Type: vhh-(+36GFP)
- Application: ICC, Neut, FuncS
- Recombinant Anti-human GLI3 Intrabody [(D-Arg)9] (IAB-B069(A))
-
- Species Reactivity: human
- Type: vhh-(D-Arg)9
- Application: IF, FC, WB, FuncS
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For Research Use Only. Not For Clinical Use.