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GPA33

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Distal enterocytes, Paneth cells, Proximal enterocytes, Intestinal goblet cells, Undifferentiated cells)

Immune cell specificity

Immune cell enhanced (naive CD4 T-cell, T-reg)

Cell line specificity

Cell line enriched (OE19)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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