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GRIK5

Engineered Antibody Antibody-like Scaffold Protein
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants.
Protein class

FDA approved drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Excitatory neurons, Oligodendrocyte precursor cells, Inhibitory neurons, Bipolar cells, Rod photoreceptor cells, Horizontal cells, Astrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HEL, hTERT-RPE1, NTERA-2, REH, SCLC-21H, SH-SY5Y)

Interaction

Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity).

Molecular function

Ion channel, Ligand-gated ion channel, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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