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GUCY2C
This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive).
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Paneth cells, Proximal enterocytes, Intestinal goblet cells, Undifferentiated cells, Distal enterocytes)
Immune cell specificity
Immune cell enhanced (memory B-cell)
Cell line specificity
Cell line enhanced (AN3-CA, CACO-2, CAPAN-2, SiHa)
Interaction
Homotrimer (PubMed:11123935). Interacts via its C-terminal region with PDZK2 (PubMed:11950846). Interacts with the lectin chaperone VIP36 (PubMed:23269669).
Molecular function
Lyase, Receptor
More Types Infomation
- Recombinant Anti-Human GUCY2C Antibody scFv Fragment (MOB-2397z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IF, FC, Biosensors, FuncS
- Recombinant Anti-Human GUCY2C Antibody Fab Fragment (MOB-2397z-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: Neut, IF, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, IP, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: ELISA, WB
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC
- Anti-Guanylyl cyclase C (clone 5F9)-vc-MMAE ADC (ADC-049LZY)
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- Target: Guanylyl cyclase C
- Linker: VC (valine-citrulline)
- Drug: MMAE (monomethyl auristatin E)
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: ELISA, FC, WB
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: ELISA, FC, WB
-
- Target: GCC
- Linker: mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl )
- Drug: MMAE (Monomethyl auristatin E)
- Rabbit Anti-GUCY2C Recombinant Antibody; scFv Fragment (HPAB-AP098-YC-S(P)) (HPAB-AP098-YC-S(P))
-
- Species Reactivity: Human
- Type: Rabbit scFv
- Application: ELISA, IHC
- Rabbit Anti-GUCY2C Recombinant Antibody; scFv Fragment (HPAB-AP097-YC-S(P)) (HPAB-AP097-YC-S(P))
-
- Species Reactivity: Human
- Type: Rabbit scFv
- Application: ELISA, IHC
- Recombinant Mouse Anti-GUCY2C Soluble TCR (CH6) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1158)
-
- Species Reactivity: Mus musculus
- Epitope: YKETLTRILPPARKL
- Mouse Anti-GUCY2C Recombinant Soluble TCR (CH6) (scTCR-405ZP-S(P))
-
- Species Reactivity: Mus musculus
- Epitope: YKETLTRILPPARKL
- Recombinant Mouse Anti-GUCY2C Soluble TCR (CH6) (C-Cys) (VS-0622-YF3866)
-
- Species Reactivity: Mus musculus
- Epitope: YKETLTRILPPARKL
- Rabbit Anti-GUCY2C Recombinant Antibody; Fab Fragment (HPAB-AP098-YC-F(E)) (HPAB-AP098-YC-F(E))
-
- Species Reactivity: Human
- Type: Rabbit Fab
- Application: ELISA, IHC
- Rabbit Anti-GUCY2C Recombinant Antibody; Fab Fragment (HPAB-AP097-YC-F(E)) (HPAB-AP097-YC-F(E))
-
- Species Reactivity: Human
- Type: Rabbit Fab
- Application: ELISA, IHC
- Rabbit Anti-GUCY2C Recombinant Antibody (HPAB-AP098-YC) (HPAB-AP098-YC)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC
- Rabbit Anti-GUCY2C Recombinant Antibody (HPAB-AP097-YC) (HPAB-AP097-YC)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC
- Anti-GCC (5F9)-Cleavable peptide linker-MMAE ADC (ADC-121LCT)
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- Target: Guanylyl cyclase C (GCC or GUCY2C)
- Linker: Cleavable peptide linker
- Drug: MMAE (Monomethyl auristatin E)
-
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human, Mouse
- Type: Chimeric (mouse/human) IgG
- Application: ELISA, FC, WB
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