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GYPA

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
Protein class

Blood group antigen proteins, CD markers

Predicted location

Membrane

Single cell type specificity

Cell type enriched (Erythroid cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (HEL, K-562)

Interaction

Homodimer. (Microbial infection) Interacts with Streptococcus gordonii hsa protein.

Molecular function

Blood group antigen, Host cell receptor for virus entry, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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