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HAVCR1
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19.
Protein class
CD markers
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Microglial cells, Proximal tubular cells, Excitatory neurons, Oligodendrocytes, Inhibitory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (A549, CACO-2, RPTEC TERT1)
Interaction
Interacts with STAM (PubMed:29742433). Interacts with SELPLG (PubMed:24703780). (Microbial infection) Interacts with hepatitis A virus capsid proteins. (Microbial infection) Interacts with Ebolavirus envelope glycoprotein GP. (Microbial infection) Interacts with Zika virus envelope protein E.
Molecular function
Host cell receptor for virus entry, Receptor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, FC, WB
-
- Derivation: Phage display library
- Species Reactivity: Rat
- Type: Rabbit IgG
- Application: ELISA
-
- Species Reactivity: Canine
- Type: Rabbit IgG
- Application: ELISA, IHC-P
- Rat Anti-Havcr1 Recombinant Antibody (clone RMT1-10) (NEUT-892CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: Neut
- Rat Anti-HAVCR1 Recombinant Antibody; scFv Fragment (TAB-0625CL-S(P)) (TAB-0625CL-S(P))
-
- Species Reactivity: Mouse
- Type: Rat scFv
- Application: ELISA, WB, FC
- Human Anti-HAVCR1 Recombinant Antibody; scFv Fragment (HPAB-1722-FY-S(P)) (HPAB-1722-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, ELISA
- Human Anti-HAVCR1 Recombinant Antibody; scFv Fragment (HPAB-1721-FY-S(P)) (HPAB-1721-FY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, ELISA
- Human Anti-HAVCR1 Recombinant Antibody; scFv Fragment (HPAB-1720-FY-S(P)) (HPAB-1720-FY-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: FC, ELISA
- Human Anti-HAVCR1 Recombinant Antibody (HPAB-1722-FY) (HPAB-1722-FY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC, ELISA
- Human Anti-HAVCR1 Recombinant Antibody (HPAB-1721-FY) (HPAB-1721-FY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: FC, ELISA
- Anti-TIM1 (CR-014)-vc-MMAE ADC (ADC-159LCT)
-
- Target: TIM1
- Linker: VC (valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
- Human Anti-HAVCR1 Recombinant Antibody; Fab Fragment (HPAB-1720-FY-F(E)) (HPAB-1720-FY-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: FC, ELISA
- Human Anti-HAVCR1 Recombinant Antibody; Fab Fragment (HPAB-0194CQ-F(E)) (HPAB-0194CQ-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, IHC, FC
- Human Anti-HAVCR1 Recombinant Antibody; Fab Fragment (HPAB-0193CQ-F(E)) (HPAB-0193CQ-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, IHC, FC
- Human Anti-HAVCR1 Recombinant Antibody; Fab Fragment (HPAB-0192CQ-F(E)) (HPAB-0192CQ-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, IHC, FC
- Human Anti-HAVCR1 Recombinant Antibody (HPAB-1720-FY) (HPAB-1720-FY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: FC, ELISA
- Human Anti-HAVCR1 Recombinant Antibody (HPAB-0194CQ) (HPAB-0194CQ)
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- Species Reactivity: Human
- Type: Human IgG2, κ
- Application: ELISA, IHC, FC, FuncS
- Human Anti-HAVCR1 Recombinant Antibody (HPAB-0193CQ) (HPAB-0193CQ)
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- Species Reactivity: Human
- Type: Human IgG4, κ
- Application: ELISA, IHC, FC, FuncS
- Human Anti-HAVCR1 Recombinant Antibody (HPAB-0192CQ) (HPAB-0192CQ)
-
- Species Reactivity: Human
- Type: Human IgG4, κ
- Application: ELISA, IHC, FC
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