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HTR3A
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Protein class
FDA approved drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Exocrine glandular cells, Pancreatic endocrine cells, Ductal cells)
Immune cell specificity
Group enriched (naive B-cell, plasmacytoid DC, memory B-cell)
Cell line specificity
Cell line enhanced (CAPAN-2, Daudi, NTERA-2, SCLC-21H)
Interaction
Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.
Molecular function
Ion channel, Ligand-gated ion channel, Receptor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Species Reactivity: Mouse
- Type: Llama VHH
- Application: FC, CA, IP, FuncS
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For Research Use Only. Not For Clinical Use.