Candidate cardiovascular disease genes, Enzymes, Plasma proteins
Intracellular, Membrane, Secreted (different isoforms)
Cell type enriched (granulocytes)
Group enriched (basophil, eosinophil)
Group enriched (HHSteC, HMC-1, HUVEC TERT2)
Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88. Interacts with TMED1 (PubMed:23319592).
Hydrolase, Receptor
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For Research Use Only. Not For Clinical Use.