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IL21R

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Protein class

Cancer-related genes, CD markers, Disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (T-cells, NK-cells, dendritic cells, B-cells, Plasma cells, Langerhans cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (Daudi, HDLM-2, Karpas-707, RH-30, RPMI-8226, U-266/70)

Interaction

Heterodimer with the common gamma subunit. Associates with JAK1.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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