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IL22RA1

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.
Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells, Exocrine glandular cells, Pancreatic endocrine cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (CACO-2, Hep G2, OE19)

Interaction

Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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