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INHBB

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Protein class

Cancer-related genes

Predicted location

Secreted

Single cell type specificity

Group enriched (Granulosa cells, Adipocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A549, ASC diff, BJ hTERT+ SV40 Large T+ RasG12V, MCF7, PC-3, SK-BR-3, T-47d)

Interaction

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.

Molecular function

Growth factor, Hormone

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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