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KCNMB3
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22.
Protein class
FDA approved drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells, Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (CACO-2, HEL, NB-4)
Interaction
Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer.
Molecular function
Ion channel
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.