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KLB

Klotho Beta contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. It probably inactive as a glycosidase and increases the ability of FGFR1 and FGFR4 to bind FGF21.
Protein class

Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Hepatocytes, Spermatocytes, Alveolar cells type 2, Enteroendocrine cells, Intestinal goblet cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (ASC diff, Hep G2)

Interaction

Interacts with FGFR1 and FGFR4 (By similarity). Interacts with FGF19; this interaction is direct. Interacts (via C-terminus) with FGF21; this interaction is direct.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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