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LEPR
Leptin receptor (LEPR, OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist.
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Hepatocytes, Microglial cells, Adipocytes, Fibroblasts, Endothelial cells, Langerhans cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (K-562, RPTEC TERT1)
Interaction
Present as a mixture of monomers and dimers (Probable). The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity) (PubMed:9600917). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (By similarity).
Molecular function
Receptor
More Types Infomation
- Recombinant Human Anti-human LEPR Antibody scFv Fragment (MHH-618-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: IP, IF, Biosensors, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IP, FuncS
-
- Species Reactivity: Human
- Application: ELISA, IHC-P, WB
- Recombinant Anti-human LEPR Antibody scFv Fragment (MOB-618-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, IHC, FuncS
- Recombinant Anti-human LEPR Antibody Fab Fragment (MOB-618-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, RIA, FuncS
- Recombinant Anti-human LEPR Antibody (MOB-618)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, IHC, FuncS
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: FC, WB
- Recombinant Human Anti-human LEPR Antibody Fab Fragment (MHH-618-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: RIA, IP, FuncS
- Human Anti-LEPR Recombinant Antibody; Fab Fragment (HPAB-0133-YC-F(E)) (HPAB-0133-YC-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
- Human Anti-LEPR Recombinant Antibody; Fab Fragment (HPAB-0132-YC-F(E)) (HPAB-0132-YC-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
- Human Anti-LEPR Recombinant Antibody (HPAB-N0167-YC) (HPAB-N0167-YC)
-
- Species Reactivity: Human
- Type: Human IgG, κ
- Application: ELISA
- Human Anti-LEPR Recombinant Antibody (HPAB-0135-YC) (HPAB-0135-YC)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC
- Human Anti-LEPR Recombinant Antibody (HPAB-0134-YC) (HPAB-0134-YC)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC
- Human Anti-LEPR Recombinant Antibody (HPAB-0133-YC) (HPAB-0133-YC)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC
- Human Anti-LEPR Recombinant Antibody (HPAB-0132-YC) (HPAB-0132-YC)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC
- Human Anti-LEPR Recombinant Antibody (HPAB-N0167-YC-S(P)); scFv Fragment (HPAB-N0167-YC-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Human Anti-LEPR Recombinant Antibody; Fab Fragment (HPAB-0135-YC-F(E)) (HPAB-0135-YC-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
- Human Anti-LEPR Recombinant Antibody; Fab Fragment (HPAB-0134-YC-F(E)) (HPAB-0134-YC-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
- Human Anti-LEPR Recombinant Antibody; scFv Fragment (HPAB-0134-YC-S(P)) (HPAB-0134-YC-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.