Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes
Membrane
Cell type enhanced (Melanocytes, granulocytes, Spermatocytes)
Not detected in immune cells
Cell line enhanced (MCF7, SK-MEL-30)
Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production (PubMed:19737927). Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes (PubMed:31097585).
G-protein coupled receptor, Receptor, Transducer
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For Research Use Only. Not For Clinical Use.