CD markers, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Intracellular, Membrane (different isoforms)
Cell type enhanced (Gastric mucus-secreting cells, Distal enterocytes, Pancreatic endocrine cells, Paneth cells, Proximal enterocytes, Intestinal goblet cells, Alveolar cells type 1)
Not detected in immune cells
Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion.
Kinase, Receptor, Transferase, Tyrosine-protein kinase
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For Research Use Only. Not For Clinical Use.