MuV HA

Mumps virus is the causative agent of mumps, a well-known common childhood disease characterised by swelling of the parotid glands, salivary glands and other epithelial tissues, causing high morbidity and in some cases more serious complications such as deafness. Natural infection is currently restricted to humans and the virus is transmitted by direct contact, droplet spread, or contaminated objects. The envelope, a lipid bilayer derived from the host-cell plasma membrane, harbours multiple copies of a number of glycoproteins required for virus entry and exit: hemagglutinin-neuraminidase (HN), fusion (F), and the small hydrophobic (SH) protein.