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NOD2
Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response.
Related Signaling Pathways
NLR Signaling Pathway
TNF Signaling Pathway
- Recombinant Mouse Anti-NOD2 Antibody [FITC] (MOB-0340MC)
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- Species Reactivity: Human, Mouse
- Application: WB, IHC, IHC-P, IP
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- Species Reactivity: Human
- Application: IHC-P, IP, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IF, IHC, IP
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For Research Use Only. Not For Clinical Use.