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PABPN1
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
May interact with SETX (PubMed:21700224). Monomer and homooligomer. Binds RNA as a monomer and oligomerizes when bound to poly(A). Interacts with PAPOLA, but only in presence of oligo(A) RNA. Interacts with transportin. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Association in a ternary complex with CPSF4 and influenza A virus NS1 blocks pre-mRNAs processing, thereby preventing nuclear export of host cell mRNAs. Associates in a single complex with SKIP and MYOD1 and interacts with SKIP in differentiated myocytes. Interacts with NUDT21/CPSF5. Interacts (via RRM domain and C-terminal arginine-rich region) with ZFP36 (via hypophosphorylated form); this interaction occurs in the nucleus in a RNA-independent manner, decreases in presence of single-stranded poly(A) RNA-oligomer and in a p38-dependent-manner and may down-regulated RNA poly(A) polymerase activity (By similarity). Component of the poly(A) tail exosome targeting (PAXT) complex made of accessory factors, such as PABPN1, ZFC3H1 and MTREX (PubMed:27871484). Interacts with ZFC3H1 in a RNase-insensitive manner (PubMed:27871484). Interacts with FRG1 (PubMed:17103222).
Molecular function
RNA-binding
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC, IHC-P, WB
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IHC
-
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, ELISA, IHC, FC, FuncS
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, IF, IP
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC, IF, FC
- Recombinant Anti-human PABPN1 Intrabody [Tat] (IAB-B060(T))
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- Species Reactivity: human
- Type: vhh-Tat
- Application: FACS, ELISA, IF, FuncS
- Recombinant Anti-human PABPN1 Intrabody [+36 GFP] (IAB-B060(G))
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- Species Reactivity: human
- Type: vhh-(+36GFP)
- Application: ELISA, ICC, FuncS
- Recombinant Anti-human PABPN1 Intrabody [(D-Arg)9] (IAB-B060(A))
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- Species Reactivity: human
- Type: vhh-(D-Arg)9
- Application: FACS, ICC, FuncS
-
- Derivation: Phage Display Library
- Type: Llama VHH
- Application: ELISA
-
- Derivation: Phage Display Library
- Type: Llama VHH
- Application: ELISA
-
- Derivation: Phage Display Library
- Type: Llama VHH
- Application: ELISA
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For Research Use Only. Not For Clinical Use.