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PLA2G10

This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism.
Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, RAS pathway related proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Distal enterocytes, Paneth cells, Intestinal goblet cells, Exocrine glandular cells, Gastric mucus-secreting cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, CAPAN-2, HaCaT, MCF7, OE19, SK-BR-3)

Interaction

Interacts with PLA2R1; this interaction mediates PLA2G10 clearance and inactivation.

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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