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PTN

The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis.
Protein class

Cancer-related genes

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Endometrial stromal cells, Muller glia cells, Horizontal cells, Squamous epithelial cells, Extravillous trophoblasts, Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (AF22)

Interaction

Interacts with ALK and NEK6 (PubMed:11278720, 20873783). Interacts with PTPRZ1 (via chondroitin sulfate groups); promotes formation of homooligomers; oligomerization impairs tyrosine phosphatase activity (PubMed:16814777) (Probable). Forms a complex with PTPRZ1 and CTNNB1; this complex inactivates PTPRZ1 protein tyrosine phosphatase activity through PTN interaction and stimulates tyrosine phosphorylation of CTNNB1 (PubMed:10706604). Interacts with ITGB3 AND ITGA5 (PubMed:19141530). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through ITGB3 'Tyr-773' phosphorylation (PubMed:19141530). Interacts with SDC3 (via heparan sulfate chains); this interaction mediates the neurite outgrowth-promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment. Interacts with GPC2 (via heparan sulfate); this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2 (By similarity).

Molecular function

Growth factor, Heparin-binding, Mitogen

More Types Infomation

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