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PTPRZ1

This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Protein class

Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (AF22, NTERA-2, WM-115)

Interaction

The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:20133774). Interacts with PTN (PubMed:16814777). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (By similarity). Interacts (via chondroitin sulfate chains) with MDK (via C-terminal); this interaction is inhibited by PTN; this interaction promotes neuronal migration (By similarity).

Molecular function

Hydrolase, Protein phosphatase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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