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RSPO2
R-spondin 2 also known as roof plate-specific spondin-2 is a protein that in humans that is encoded by the RSPO2 gene.
R-spondin 2 synergizes with Wnt to activate beta-catenin. RSPO2 has been proposed to regulate craniofacial patterning and morphogenesis within pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway.
R-spondin 2 synergizes with Wnt to activate beta-catenin. RSPO2 has been proposed to regulate craniofacial patterning and morphogenesis within pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Group enriched (Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HEK93, U-266/70)
Interaction
Interacts with WNT1 (By similarity). Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6 (PubMed:21909076, PubMed:21727895, PubMed:22615920, PubMed:29769720). Interacts with E3 ubiquitin ligases RNF43 and ZNRF3 (PubMed:29769720).
Molecular function
Developmental protein, Heparin-binding
More Types Infomation
- Recombinant Rat Anti-RSPO2 Antibody (CBL669) (NEUT-1923CQ)
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- Species Reactivity: Human
- Type: IgG1
- Application: Neut
- Anti-Human RSPO2 Recombinant Antibody scFv Fragment (130M24) (TAB-0227CL-S(P))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
- Anti-Human RSPO2 Recombinant Antibody scFv Fragment (130M23) (TAB-0226CL-S(P))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse IgG
- Application: WB, ELISA, Neut, FC, IHC, IP
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse IgG
- Application: WB, ELISA, Neut, FC, IHC, IP
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse IgG
- Application: WB, ELISA, Neut, FC, IHC, IP
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse IgG
- Application: WB, ELISA, Neut, FC, IHC, IP
- Human Anti-RSPO2 Recombinant Antibody; Fab Fragment (HPAB-0307-WJ-F(E)) (HPAB-0307-WJ-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse scFv
- Application: WB, ELISA, Neut, FC, IHC, IP
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M27) (TAB-0230CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M26) (TAB-0229CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M25) (TAB-0228CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M24) (TAB-0227CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M23) (TAB-0226CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
- Mouse Anti-RSPO2 Recombinant Antibody; Fab Fragment (TAB-348CT-F(E)) (TAB-348CT-F(E))
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse Fab
- Application: WB, ELISA, Neut, FC, IHC, IP
- Mouse Anti-RSPO2 Recombinant Antibody; Fab Fragment (TAB-347CT-F(E)) (TAB-347CT-F(E))
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse Fab
- Application: WB, ELISA, Neut, FC, IHC, IP
- Mouse Anti-RSPO2 Recombinant Antibody; Fab Fragment (TAB-346CT-F(E)) (TAB-346CT-F(E))
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse Fab
- Application: WB, ELISA, Neut, FC, IHC, IP
- Human Anti-RSPO2 Recombinant Antibody; scFv Fragment (HPAB-0307-WJ-S(P)) (HPAB-0307-WJ-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse scFv
- Application: WB, ELISA, Neut, FC, IHC, IP
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse scFv
- Application: WB, ELISA, Neut, FC, IHC, IP
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For Research Use Only. Not For Clinical Use.