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SCN9A
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Hofbauer cells, Inhibitory neurons, dendritic cells, Langerhans cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, HHSteC, hTERT-RPE1)
Interaction
The sodium channel complex consists of a large, channel-forming alpha subunit (SCN9A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B) (PubMed:7720699, 17167479, 25240195). SCN1B and SCN3B are non-covalently associated with SCN2A. SCN2B and SCN4B are disulfide-linked to SCN2A. Interacts with NEDD4 and NEDD4L (By similarity). Interacts with the scorpion alpha-toxin CvIV4 (PubMed:21887265). Interacts with the conotoxin GVIIJ (PubMed:24497506). Interacts with the spider huwentoxin-IV (through the extracellular loop S3-S4 of repeat II) (PubMed:20855463, 21659528, 30661758, 30765606). Interacts with the spider protoxin-II (through the extracellular loop S3-S4 of repeats II and IV) (PubMed:20855463, 21659528, 30661758, 30765606). Interacts with the spider beta/delta-theraphotoxin-Pre1a (PubMed:28428547).
Molecular function
Ion channel, Sodium channel, Voltage-gated channel
More Types Infomation
- Recombinant Human Anti-human SCN9A Antibody scFv Fragment (MHH-891-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, IHC, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, Neut, FuncS
- Recombinant Human Anti-human SCN9A Antibody Fab Fragment (MHH-891-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA
- Recombinant Anti-human SCN9A Antibody (MOB-891)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC, FuncS
- Recombinant Anti-human SCN9A Antibody Fab Fragment (MOB-891-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, RIA, FuncS
- Recombinant Anti-human SCN9A Antibody scFv Fragment (MOB-891-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, IP, FuncS
- Recombinant Mouse Anti-SCN9A Monoclonal Antibody (1D6) (MRO-1062-CN)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: IHC, IF, FC, WB
- Rabbit Anti-SCN9A Polyclonal Antibody (MRO-2056-CN) (MRO-2056-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IF, IHC, FC
- Rabbit Anti-SCN9A Polyclonal Antibody (MRO-2057-CN) (MRO-2057-CN)
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: IF, IHC
- Human Anti-SCN9A Recombinant Antibody; Fab Fragment (TAB-0334CL-F(E)) (TAB-0334CL-F(E))
-
- Species Reactivity: No Cross-reactivity with Nav1.5
- Type: Human Fab
- Application: FuncS, IHC, Block, Inhib, ELISA
- Human Anti-SCN9A Recombinant Antibody (TAB-0334CL) (TAB-0334CL)
-
- Species Reactivity: No Cross-reactivity with Nav1.5
- Type: Human IgG
- Application: FuncS, IHC, Block, Inhib, ELISA
- Anti-Human SCN9A Recombinant Antibody (9A11) (TAB-473MZ)
-
- Derivation: Library
- Application: ELISA
- Anti-Human SCN9A Recombinant Antibody (9A6) (TAB-472MZ)
-
- Derivation: Library
- Application: ELISA
- Anti-Human SCN9A Recombinant Antibody (9A1) (TAB-471MZ)
-
- Derivation: Library
- Application: ELISA
- Anti-Human SCN9A Recombinant Antibody Fab Fragment (9A11) (TAB-473MZ-F(E))
-
- Derivation: Library
- Application: ELISA, FuncS
- Anti-Human SCN9A Recombinant Antibody Fab Fragment (9A6) (TAB-472MZ-F(E))
-
- Derivation: Library
- Application: ELISA, FuncS
- Anti-Human SCN9A Recombinant Antibody Fab Fragment (9A1) (TAB-471MZ-F(E))
-
- Derivation: Library
- Application: ELISA, FuncS
- Anti-Human SCN9A Recombinant Antibody Fab Fragment (8B6) (TAB-470MZ-F(E))
-
- Derivation: Library
- Application: ELISA, FuncS
- Anti-Human SCN9A Recombinant Antibody Fab Fragment (8A7) (TAB-469MZ-F(E))
-
- Derivation: Library
- Application: ELISA, FuncS
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