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SERPINA1
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Group enriched (non-classical monocyte, intermediate monocyte, neutrophil, classical monocyte)
Cell line specificity
Cell line enriched (Hep G2)
Interaction
Interacts with CELA2A (PubMed:31358993). Interacts with ERGIC3 and LMAN1/ERGIC53 (PubMed:31142615). Interacts with PRSS1/trypsin (PubMed:11057674). Interacts with PRSS1/Trypsin (PubMed:11057674). The variants S and Z interact with CANX AND PDIA3 (PubMed:23826168).
Molecular function
Protease inhibitor, Serine protease inhibitor
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
- Mouse Anti-SERPINA1 Recombinant Antibody (clone 2H2); Fab Fragment (PABJ-0203-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: IF, FuncS
- Mouse Anti-SERPINA1 Recombinant Antibody (clone 1D9); Fab Fragment (PABJ-0157-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-SERPINA1 Recombinant Antibody (clone 2H2); scFv Fragment (PABJ-0203-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: IF, FuncS
- Rabbit Anti-SERPINA1 Polyclonal Antibody (MRO-1639-CN) (MRO-1639-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, IHC-P, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, Dot, ELISA
- Mouse Anti-SERPINA1 Recombinant Antibody (clone 1D9); scFv Fragment (PABJ-0157-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IF, FuncS
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
-
- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ELISA
- Mouse Anti-SERPINA1 Recombinant Antibody (clone 3H12-2C2); scFv Fragment (HPAB-0408-YJ-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, Inhib
- Mouse Anti-SERPINA1 Recombinant Antibody (clone 3H12-2C2); Fab Fragment (HPAB-0408-YJ-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, Inhib
- Chicken Anti-alpha-1 Antitrypsin Polyclonal IgY (BRD-0846MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.