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SERPINA5
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Cholangiocytes, Glandular and luminal cells, Late spermatids, Hepatocytes, Endometrial ciliated cells, Peritubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (Hep G2)
Interaction
Forms protease inhibiting heterodimers in extracellular body fluids with serine proteases such as activated protein C/coagulation factor V/F5, acrosin/ACR, chymotrypsinogen B/CTRB1, prothrombin/F2, factor Xa/F10, factor XI/F11, kallikrein/KLKB1, tissue kallikrein, trypsin/PRSS1, prostate specific antigen/KLK3, tissue plasminogen activator/PLAT and urinary plasminogen activator/PLAU. Forms membrane-anchored serine proteases inhibiting heterodimers with TMPRSS7 and TMPRSS11E. Interacts with SEMG2.
Molecular function
Heparin-binding, Protease inhibitor, Serine protease inhibitor
More Types Infomation
- Rabbit Anti-SERPINA5 Polyclonal Antibody (MRO-2106-CN) (MRO-2106-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Type: IgG
- Application: ELISA
- Human Anti-SERPINA5 Antibody, mRNA (TAB-560CL-mRNA)
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- Species Reactivity: Human
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Mouse Anti-SERPINA5 Recombinant Antibody (clone PC19G8); Fab Fragment (HPAB-1917-FY-S(P))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: Neut, ELISA
- Mouse Anti-SERPINA5 Recombinant Antibody (clone PC19G8); scFv Fragment (HPAB-1917-FY-F(E))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: Neut, ELISA
- Mouse Anti-SERPINA5 Recombinant Antibody (clone PC19G8) (HPAB-1917-FY)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, ELISA
- Mouse Anti-SERPINA5 Recombinant Antibody (clone PC23D8); Fab Fragment (HPAB-1916-FY-S(P))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: Neut, ELISA
- Mouse Anti-SERPINA5 Recombinant Antibody (clone PC23D8); scFv Fragment (HPAB-1916-FY-F(E))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: Neut, ELISA
- Mouse Anti-SERPINA5 Recombinant Antibody (clone PC23D8) (HPAB-1916-FY)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: Neut, ELISA
- Anti-Human SERPINA5 Recombinant Antibody scFv Fragment (PC23A7) (TAB-0947CL-S(P))
-
- Application: SDS-PAGE, WB
- Anti-Human SERPINA5 Recombinant Antibody scFv Fragment (PC31E2) (TAB-0946CL-S(P))
-
- Application: SDS-PAGE, WB
- Anti-Human SERPINA5 Recombinant Antibody Fab Fragment (PC23A7) (TAB-0947CL-F(E))
-
- Application: SDS-PAGE, WB
- Anti-Human SERPINA5 Recombinant Antibody Fab Fragment (PC31E2) (TAB-0946CL-F(E))
-
- Application: SDS-PAGE, WB
- Anti-Human SERPINA5 Recombinant Antibody (PC23A7) (TAB-0947CL)
-
- Application: SDS-PAGE, WB
- Anti-Human SERPINA5 Recombinant Antibody (PC31E2) (TAB-0946CL)
-
- Application: SDS-PAGE, WB
- Anti-Human SERPINA5 Recombinant Antibody (TAB-560CL)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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