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SIGLEC7

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Protein class

CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (NK-cells, Kupffer cells, Macrophages, Hofbauer cells, monocytes)

Immune cell specificity

Immune cell enhanced (eosinophil)

Cell line specificity

Group enriched (Karpas-707, RPMI-8226, U-937)

Interaction

Interacts with PTPN6/SHP-1 upon phosphorylation.

More Types Infomation

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