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SLC11A1

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Protein class

Metabolic proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Macrophages, Kupffer cells, Hofbauer cells, monocytes)

Immune cell specificity

Group enriched (classical monocyte, non-classical monocyte, intermediate monocyte, neutrophil, myeloid DC)

Cell line specificity

Cell line enhanced (HEL, HMC-1)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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