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SNAP25
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Bipolar cells, Inhibitory neurons, Rod photoreceptor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Karpas-707, SCLC-21H, SH-SY5Y, U-87 MG)
Interaction
Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1 (PubMed:11832227). Found in a complex containing SYT1, SV2B and syntaxin-1 (By similarity). Found in a ternary complex with STX1A and VAMP8 (By similarity). Interacts with HSC70 and with SYT9, forming a complex with DNAJC5 (By similarity). The interaction with SYT9 is inhibited in presence of calcium (By similarity). Isoform 1 and isoform 2 interact with BLOC1S6 (PubMed:19546860). Interacts with CENPF (By similarity). Interacts with EQTN (By similarity). Interacts with HGS (By similarity). Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells (By similarity). Interacts with OTOF (By similarity). Interacts with RIMS1 (By similarity). Interacts with SNAPIN (By similarity). Interacts with STXBP6 (By similarity). Interacts with TRIM9 (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895, 28757145). Associates with the BLOC-1 complex (PubMed:19546860). Interacts with PLCL1 (via C2 domain) (By similarity). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex (PubMed:22832103, 25915028). Interacts with alpha-synuclein/SNCA (PubMed:20798282). Interacts with PRPH2 (By similarity). Interacts with ROM1 (By similarity). Interacts with STX3 (By similarity).
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, ICC/IF
-
- Species Reactivity: N/A
- Type: Mouse antibody
- Application: ELISA, IHC
- Recombinant Human Anti-SNAP25 Antibody Fab Fragment (MHH-912-F(E))
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- Derivation: Human
- Type: Fab
- Application: WB, ELISA, IHC, FuncS
- Recombinant Human Anti-SNAP25 Antibody (MHH-912)
-
- Derivation: Human
- Type: IgG
- Application: WB, FuncS
- Recombinant Anti-SNAP25 Antibody scFv Fragment (MOB-912-S(P))
-
- Derivation: Mouse
- Type: scFv
- Application: ELISA, IP, FuncS
- Recombinant Anti-SNAP25 Antibody Fab Fragment (MOB-912-F(E))
-
- Derivation: Mouse
- Type: Fab
- Application: RIA, IF, FuncS
- Recombinant Anti-SNAP25 Antibody (MOB-912)
-
- Derivation: Mouse
- Type: IgG
- Application: ELISA, WB, FuncS
- Recombinant Human Anti-SNAP25 Antibody scFv Fragment (MHH-912-S(P))
-
- Derivation: Human
- Type: scFv
- Application: WB, IHC, FuncS
-
- Species Reactivity: Human
- Application: ELISA, IHC-P, WB
- Mouse Anti-SNAP25 Antibody (clone SP12), mRNA (FAMAB-1551CQ-mRNA)
-
- Species Reactivity: Cat, Bovine, Guinea pig, Hamster, Pig, Human, Mouse, Rat
- Mouse Anti-SNAP-25 Recombinant Antibody (clone SP12) (FAMAB-1551CQ)
-
- Species Reactivity: Cat, Bovine, Guinea Pig, Hamster, Pig, Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB, ELISA, IF, IHC
- Mouse Anti-SNAP25 Recombinant Antibody; scFv Fragment (HPAB-0019-CN-S(P)) (HPAB-0019-CN-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse scFv
- Application: ELISA, ICC, IP
- Mouse Anti-SNAP25 Recombinant Antibody; Fab Fragment (HPAB-0022-CN-F(E)) (HPAB-0022-CN-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse Fab
- Application: ELISA, ICC, IP
- Mouse Anti-SNAP25 Recombinant Antibody; scFv Fragment (HPAB-0023-CN-S(P)) (HPAB-0023-CN-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse scFv
- Application: ELISA, ICC, IHC
- Mouse Anti-SNAP25 Recombinant Antibody; scFv Fragment (HPAB-0022-CN-S(P)) (HPAB-0022-CN-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse scFv
- Application: ELISA, ICC, IP
- Mouse Anti-SNAP25 Recombinant Antibody; scFv Fragment (HPAB-0021-CN-S(P)) (HPAB-0021-CN-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse scFv
- Application: ELISA, ICC, IP
- Mouse Anti-SNAP25 Recombinant Antibody; scFv Fragment (HPAB-0020-CN-S(P)) (HPAB-0020-CN-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse scFv
- Application: ELISA, ICC, IP
- Mouse Anti-SNAP25 Recombinant Antibody; Fab Fragment (HPAB-0021-CN-F(E)) (HPAB-0021-CN-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse Fab
- Application: ELISA, ICC, IP
- Mouse Anti-SNAP25 Recombinant Antibody; Fab Fragment (HPAB-0020-CN-F(E)) (HPAB-0020-CN-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse Fab
- Application: ELISA, ICC, IP
- Mouse Anti-SNAP25 Recombinant Antibody; Fab Fragment (HPAB-0019-CN-F(E)) (HPAB-0019-CN-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse Fab
- Application: ELISA, ICC, IP
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For Research Use Only. Not For Clinical Use.