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SPP1
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Hofbauer cells)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (EFO-21, Hep G2, RPTEC TERT1)
Interaction
Ligand for integrin alpha-V/beta-3.
Molecular function
Cytokine
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, ICC, IF, IHC, WB
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC/IF, IHC-P, WB
- Rabbit Anti-SPP1 Polyclonal Antibody (MRO-2098-CN) (MRO-2098-CN)
-
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: WB
- Rabbit Anti-SPP1 Polyclonal Antibody (MRO-2099-CN) (MRO-2099-CN)
-
- Species Reactivity: Human, Zebrafish
- Type: Rabbit IgG
- Application: WB, IHC, FC
-
- Species Reactivity: Human
- Application: WB
- Rabbit Anti-SPP1 Polyclonal Antibody (MRO-2100-CN) (MRO-2100-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IHC, ELISA
- Rabbit Anti-SPP1 Polyclonal Antibody (MRO-2101-CN) (MRO-2101-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IF, IHC, ELISA
- Human Anti-SPP1 Antibody (clone hu1A12), mRNA (FAMAB-1252CQ-mRNA)
-
- Species Reactivity: Human
- Human Anti-SPP1 Recombinant Antibody (clone hu1A12) (FAMAB-1252CQ)
-
- Species Reactivity: Human
- Type: Human IgG1
- Application: WB, IF, ELISA, Inhib, Cyt
- Anti-Human SPP1 Recombinant Antibody Fab Fragment (2K1) (TAB-0843CL-F(E))
-
- Application: sELISA
- Anti-Human SPP1 Recombinant Antibody scFv Fragment (mAb 21-5-4) (TAB-0261CL-S(P))
-
- Application: ELISA, WB
- Anti-Human SPP1 Recombinant Antibody scFv Fragment (mAb 9-3-1) (TAB-0260CL-S(P))
-
- Application: ELISA, WB
- Anti-Human SPP1 Recombinant Antibody scFv Fragment (mAb 7-5-4) (TAB-0259CL-S(P))
-
- Application: ELISA, WB
- Anti-Human SPP1 Recombinant Antibody scFv Fragment (mAb 4-4-2) (TAB-0258CL-S(P))
-
- Application: ELISA, WB
- Anti-Human SPP1 Recombinant Antibody (ASK8007) (TAB-582CL)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Anti-Human SPP1 Recombinant Antibody scFv Fragment (MOR-6991) (TAB-0847CL-S(P))
-
- Derivation: Phagemid library
- Type: Human antibody
- Application: ELISA
- Anti-Human SPP1 Recombinant Antibody scFv Fragment (MOR-6990) (TAB-0846CL-S(P))
-
- Derivation: Phagemid library
- Type: Human antibody
- Application: ELISA
- Rabbit Anti-Spp1 Recombinant Antibody; scFv Fragment (TAB-0845CL-S(P)) (TAB-0845CL-S(P))
-
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: sELISA
- Anti-Human SPP1 Recombinant Antibody scFv Fragment (4C1) (TAB-0844CL-S(P))
-
- Application: sELISA
- Anti-Human SPP1 Recombinant Antibody scFv Fragment (2K1) (TAB-0843CL-S(P))
-
- Application: sELISA
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For Research Use Only. Not For Clinical Use.