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TFF1

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Group enriched (Pancreatic endocrine cells, Gastric mucus-secreting cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (MCF7, OE19)

Interaction

Heterodimer with GKN2; disulfide linked.

Molecular function

Growth factor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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