Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins
Intracellular
Cell type enhanced (Extravillous trophoblasts, Erythroid cells, Cytotrophoblasts, Hofbauer cells)
Immune cell enhanced (T-reg)
Low cell line specificity
Homotetramer (PubMed:15611477, PubMed:15733844, PubMed:17407781, PubMed:22385435, PubMed:14697231). Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine (PubMed:14697231). Tetramerization is inhibited by phosphorylation at Ser-13 (PubMed:14697231). Interacts (via the KEN box) with FZR1 (PubMed:14701726).
Kinase, Transferase
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For Research Use Only. Not For Clinical Use.