Metabolic proteins, Plasma proteins
Intracellular
Cell type enriched (monocytes)
Low immune cell specificity
Cell line enhanced (OE19)
Homodimer; disulfide-linked (PubMed:9369469, 17260951). Interacts with TXNIP through the redox-active site (PubMed:17260951). Interacts with MAP3K5 and CASP3 (PubMed:15246877). In case of infection, interacts with S. typhimurium protein slrP (PubMed:19690162). Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (PubMed:9108029).
Activator
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For Research Use Only. Not For Clinical Use.