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TXN

The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Protein class

Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (monocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (OE19)

Interaction

Homodimer; disulfide-linked (PubMed:9369469, 17260951). Interacts with TXNIP through the redox-active site (PubMed:17260951). Interacts with MAP3K5 and CASP3 (PubMed:15246877). In case of infection, interacts with S. typhimurium protein slrP (PubMed:19690162). Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (PubMed:9108029).

Molecular function

Activator

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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