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VEGFB

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Protein class

Cancer-related genes, FDA approved drug targets, RAS pathway related proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Cardiomyocytes, Muller glia cells)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Low cell line specificity

Interaction

Homodimer; disulfide-linked. Can also form heterodimer with VEGF.

Molecular function

Growth factor, Heparin-binding, Mitogen

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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