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ABCC3

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Gastric mucus-secreting cells, Distal enterocytes, Cholangiocytes, Paneth cells, Hepatocytes)

Immune cell specificity

Immune cell enhanced (non-classical monocyte, intermediate monocyte)

Cell line specificity

Cell line enhanced (A549, CAPAN-2, HeLa, OE19)

Molecular function

Translocase

More Types Infomation

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