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ACAN
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Group enriched (Granulosa cells, Extravillous trophoblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (WM-115)
Interaction
Interacts with FBLN1 (By similarity). Interacts with COMP.
More Types Infomation
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- Class: Class II
- Antigen: ACAN
- Antigen Species: Human
- Peptide: ATEYRVRVNSAYQDK
- Conjugate: BV421
-
- Class: Class II
- Antigen: ACAN
- Antigen Species: Human
- Peptide: ATEYRVRVNSAYQDK
- Conjugate: PE
-
- Class: Class II
- Antigen: ACAN
- Antigen Species: Human
- Peptide: ATEYRVRVNSAYQDK
- Conjugate: APC
-
- Class: Class II
- Antigen: cit aggrecan
- Antigen Species: Human
- Peptide: ATEG[cit]V[cit]VNSAYQDK
- Conjugate: Biotin
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, IHC
- Rabbit Anti-ACAN Recombinant Antibody (clone JA40-23) (MRO-0036-CN)
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: IHC
- Mouse Anti-ACAN Recombinant Antibody (clone 7-C-5) (MOB-0499MZ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IF, IHC-Fr, IHC-P, WB
- Recombinant Mouse Anti-ACAN Soluble TCR (5/4E8) (C-Cys) (VS-0622-YF4067)
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- Species Reactivity: Human
- Epitope: ATEGRVRVNSAYQDK
- MHC: H2-IAd
- Mouse Anti-ACAN Recombinant Soluble TCR (clone (5/4E8)-4) (scTCR-0061YC-S(P))
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- Species Reactivity: Human
- Epitope: ATEGRVRVNSAYQDK + CITR(R7)
- MHC: H2-IAd
- Recombinant Mouse Anti-ACAN Soluble TCR (5/4E8) (KIH) (VS-0622-YF6775)
-
- Species Reactivity: Human
- Epitope: ATEGRVRVNSAYQDK
- MHC: H2-IAd
- Recombinant Mouse Anti-ACAN Soluble TCR (5/4E8) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1359)
-
- Species Reactivity: Human
- Epitope: ATEGRVRVNSAYQDK
- MHC: H2-IAd
- Mouse Anti-ACAN Recombinant Soluble TCR (clone (5/4E8)-3) (scTCR-0060YC-S(P))
-
- Species Reactivity: Human
- Epitope: ATEGRVRVNSAYQDK + CITR(R5, R7)
- MHC: H2-IAd
- Mouse Anti-ACAN Recombinant Soluble TCR (clone (5/4E8)-2) (scTCR-0059YC-S(P))
-
- Species Reactivity: Human
- Epitope: ATEGRVRVNSAYQDK + CITR(R5)
- MHC: H2-IAd
- Mouse Anti-ACAN Recombinant Soluble TCR (clone (5/4E8)-1) (scTCR-0058YC-S(P))
-
- Species Reactivity: Human
- Epitope: ATEGRVRVNSAYQDK
- MHC: H2-IAd
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For Research Use Only. Not For Clinical Use.