Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters
Intracellular
Cell type enriched (Cardiomyocytes)
Not detected in immune cells
Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, HEK93, HSkMC, hTEC/SVTERT24-B)
Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. Interacts with SYNPO2.
Actin-binding
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For Research Use Only. Not For Clinical Use.