Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters
Intracellular, Secreted (different isoforms)
Cell type enhanced (Collecting duct cells, Basal respiratory cells, Ductal cells, Pancreatic endocrine cells)
Not detected in immune cells
Cell line enhanced (CAPAN-2, EFO-21, HaCaT)
Monomer (By similarity). Interacts (N-terminal subunit) with TGF-beta family members, BMP2 AND BMP4; the interactions inhibit the activity of these growth factors. Interacts with TGFB1; the interaction enhances the activity of TGFB1 (By similarity). Component of the AGRN-LRP4 complex that consists of a tetramer of two AGRN-LRP4 heterodimers. Interacts (via the laminin G-like 3 domain) directly with LRP4; the interaction is required for activation of MUSK and clustering of AChR and requires the 'z8' insert present in the z(+8) isoforms. Interacts with DAG1; the interaction is influenced by cell surface glycosaminoglycans and by alternative splicing of AGRN.
Developmental protein
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For Research Use Only. Not For Clinical Use.