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AGRN

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Collecting duct cells, Basal respiratory cells, Ductal cells, Pancreatic endocrine cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (CAPAN-2, EFO-21, HaCaT)

Interaction

Monomer (By similarity). Interacts (N-terminal subunit) with TGF-beta family members, BMP2 AND BMP4; the interactions inhibit the activity of these growth factors. Interacts with TGFB1; the interaction enhances the activity of TGFB1 (By similarity). Component of the AGRN-LRP4 complex that consists of a tetramer of two AGRN-LRP4 heterodimers. Interacts (via the laminin G-like 3 domain) directly with LRP4; the interaction is required for activation of MUSK and clustering of AChR and requires the 'z8' insert present in the z(+8) isoforms. Interacts with DAG1; the interaction is influenced by cell surface glycosaminoglycans and by alternative splicing of AGRN.

Molecular function

Developmental protein

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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