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ALOX5
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (granulocytes, Macrophages, Hofbauer cells, Kupffer cells, B-cells, monocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BEWO, Daudi, HMC-1, U-266/70, U-698)
Interaction
Homodimer (PubMed:22516296, PubMed:21233389). Interacts with ALOX5AP and LTC4S (PubMed:19233132). Interacts with COTL1, the interaction is required for stability and efficient catalytic activity (PubMed:19807693). Interacts with PIK3R1; this interaction bridges ALOX5 with CD40 after CD40 ligation in B cells and leads to the production of reactive oxygen species (ROS) (PubMed:21200133). Interacts (via PLAT domain) with DICER1 (via Dicer dsRNA-binding fold domain); this interaction enhances arachidonate 5-lipoxygenase activity and modifies the miRNA precursor processing activity of DICER1 (PubMed:19022417).
Molecular function
Dioxygenase, Hydrolase, Oxidoreductase
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human, Predicted to work with: Dog
- Type: Rabbit IgG
- Application: WB, IHC-P, IF
- Rabbit Anti-ALOX5 Polyclonal Antibody (MRO-1621-CN) (MRO-1621-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-F, IHC-P, ICC, IF, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC
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For Research Use Only. Not For Clinical Use.