AMBP

Plasma proteins

Intracellular, Secreted (different isoforms)

Cell type enriched (Hepatocytes)

Not detected in immune cells

Cell line enriched (Hep G2)

[Alpha-1-microglobulin]: Monomer (PubMed:22512701, PubMed:9183005). Homodimer (PubMed:9183005). In plasma, it occurs as a monomer or dimer and in covalently-linked complexes with immunoglobulin A (IgA), ALB/albumin and F2/prothrombin (PubMed:9183005). Chromophore-bound alpha-1-microglobulin interacts with the constant region of immunoglobulin A (PubMed:9183005). Chromophore-bound alpha-1-microglobulin interacts with ALB with molar ratio 2:1 and 1:1; this interaction does not prevent fatty acid binding to ALB (PubMed:9183005). Interacts with F2/prothrombin (via N-terminus) with molar ratio 2:1 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin (PubMed:9183005). Interacts with NDUFAB1, a subunit of mitochondrial complex I (PubMed:23157686). Interacts with FN1 (By similarity). [Inter-alpha-trypsin inhibitor light chain]: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of ITIH3/HC3 and bikunin (PubMed:2476436, PubMed:16873769). Interacts with TNFAIP6 (via Link domain) (PubMed:15917224). [Trypstatin]: Monomer. Also occurs as a complex with tryptase in mast cells. [Alpha-1-microglobulin]: (Microbial infection) Interacts with hepatitis E virus/HEV protein ORF3. [Inter-alpha-trypsin inhibitor light chain]: (Microbial infection) Interacts with hepatitis E virus/HEV protein ORF3.

Protease inhibitor, Serine protease inhibitor