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ANTXR2
This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Endometrial stromal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff, HHSteC, LHCN-M2, U-2197)
Interaction
Binds laminin, and possibly also collagen type IV. (Microbial infection) Interacts (via VWFA domain) with the protective antigen (PA) of B.anthracis.
Molecular function
Receptor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC
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For Research Use Only. Not For Clinical Use.