Loading...
Custom Services order now ship next day

ANXA2

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class

Cancer-related genes, FDA approved drug targets, Plasma proteins, Transporters

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Basal respiratory cells, Pancreatic endocrine cells, Prostatic glandular cells, Urothelial cells)

Immune cell specificity

Group enriched (basophil, myeloid DC, classical monocyte, non-classical monocyte, intermediate monocyte, T-reg)

Cell line specificity

Low cell line specificity

Interaction

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH (PubMed:21886777). Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR (PubMed:18799458). Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (PubMed:14522961). Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity). Interacts with S100A4 (PubMed:28669632). (Microbial infection) Interacts with human cytomegalovirus (HCMV).

Molecular function

RNA-binding

More Types Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

For Research Use Only. Not For Clinical Use.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare