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ANXA4

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
Protein class

Cancer-related genes, FDA approved drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cholangiocytes, Ductal cells, Proximal enterocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (EFO-21, Hep G2, RPTEC TERT1)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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